1963: No One Escapes... The Fury! (1963 #2)

"The Fury", a character who is somewhat analogous to Spider-Man, is hired to help protect the transport of a very large and mysterious crate, assisting the US Government agency "L.A.S.E.R.", ( analogous to S.H.I.E.L.D. from Marvel), directed by the female character "Commander Solo". The Fury encounters a villain called Voidoid while trying to protect the crate.